Over the past several years, biopharmaceutical developer Shire has been working to implement a major overhaul of the way data is handled at their pilot plant in Lexington, Massachusetts. Before implementing the PI System, the company was generating, processing, and storing data in a complicated series of networks and standalone data islands and relying heavily on spreadsheets and manual data entry. One by one, Shire is integrating all of these diverse data sources into a single solution, the PI System. At the OSIsoft's 2016 Users Conference in San Francisco, Paul Turvey and Brad Ebel of Shire, presented how this project has streamlined the flow of information, improved user access to data, reduced errors, and had a substantial impact on the bottom line.